Before you disappear down the rabbit hole, know one thing. Our mentor JC from Tool is one of the grandfathers of bi-amping. Meaning he puts out a channel that's mainly clean sub sonic with a bit of high pass filtering and another channel that's got grit and chorus. Once you enter into this realm you can easily tune down to low C and even B and blend out that pesky buzz. I do it, and if it ain't happening then ain't happening at all.
You can do it with an ABY pedal and two amps, you can do it with a pedal that has dry and wet preamps plus a blend or you can do it with most modern pedals that have a single blend.
Its a mixture of filtering out the buzz at the bass (pull the tone back) and then adding it back in with the preamp. Its a really complicated, but audiophiles way, of adding compression/sustain.
Once you get the tone you're after, headphones are the key here, turn off the amp and check for buzz. When playing with a high level of attack its impossible to avoid but clever articulation and said, "compression", will make it disappear at the speaker. I live in the land of Dropped D and its very satisfying.