The TL606 was designed for the ElectroVoice EV 15L, or EV15B. I've got the Mesa Boogie, Road Ready Diesel version of this cab, and I'll tell you, it is a great cab, (with the EV driver it was designed for). I have used it with a PF-500, and a B-15, and it works great. I also have a couple double baffle B-15 cabs, and if I was going to build my own, I would go with the TL606 for ease of building, (and because I have a couple EV 15 drivers sitting around). You could build one with very simple tools. I could not advise you as to how it would work with an Altec 421, (but I would really like to know, because I have one that needs a re-cone). I am sure there are some speaker geniuses around here who are knowledgeable about the various speaker cabinet design software, who could plug in the specs for the 421 and compare it to the TL606, and give you an idea if they are somewhat compatible, but, as good as the software may be, "the proof is in the pudding", so maybe you should build one of each, and see what the result is, and let us know.