Guys:
First of all, thanks for all the comments. Glad to hear almost all of you don't notice this issue.
The setup I generally use with the Shuttle 3.0 is is pretty simple. I run a Fender Jazz passive bass (upgraded with Lindy Fralin noise canceling pickups) directly into the amp. No effects. The amp drives a Genz-Benz 10T cab which does have a tweeter. No tweeter level control.
But the hiss is not related to the guitar. I hear the exact same thing when I unplug the bass. Hiss from the "mid-scoop" and "H.F. Attack" signal shape buttons.
For grins I ran the shuttle through a Epifani UL2 12" cab I have. This does have a tweeter level control and I cranked it all the way down. Less pronounced hiss but still there.
The noise is not really that noticeable in playing situations. But it bugs me just a little so I simply don't use those two buttons. Even without them I'm still happy with the Shuttle 3.0 -- overall it is a great little amp.
No tweeter attenuator is probably the issue... a hot tweeter, especially a cheaper piezo (not sure if that is what is in there), and significant treble boost can easily result in what you are hearing.
Of course, you won't hear any upper treble either, which may or may not be a good thing, depending on your tone goals.
I was just checking out the GB 9.0 with my upright in my basement and the hissing (with occasional crackle and sizzle) was not apparent. Then I put the amp on standby so I could dig in and practice without waking my family, and 10 minutes later, lo and behold, the crackle comes back for about 5 seconds and then fades away. I turned the standby off and didn't hear any more, shut the amp down and came up to post here again.