Yes, obviously, as we all know how sound changes as we walk around in a room. However:
1. The problem of different radiating patterns from different speaker designs remain, even if you do this in a sound lab. (So where to put the microphone in relation to the transducer positions on the baffle?)
Multiple microphones (or "measuring points", actually) will solve this, if you want data not only from directly in front of the baffle. Sure enough, this will also apply to the setup at home, with room resonances....
2. By setting, and adhering to, solid points of reference, you can get the same precision doing measurements at home. With sticky tape, fixed mike stands, rulers and good notes, you can get very high accuracy.
3. The irregularities and variations in "in room" response are basically inversely proportional to the frequency of the sound. So in a moderate size living room, the range that is most impactful to bass cabinet design, like below 2-300 Hz is not much affected by this. Higher up, in the "voicing" area of the sound, differences are more related to tranducer design, rather than cabinet design.
So, as long as one understands the difference between ABSOLUTE measurements, and RELATIVE measurements, there is nothing stopping you from getting consistent and very usable results in a non-lab setup, for the latter. And with modern, computer supported test gear, pulsed signals, wave file anayzing etc, one can do a lot even at home, or in a rehearsal studio.
I think people with various levels of experience and training in engineering and design should PROMOTE experimentation and projects, not scare people away. While gear and lab conditions are a blessing, one can get very useful results and insights with small resources, as long as there is a willingness to learn, and patience to do things right.