Yeah - technique is very important, but I don't care how perfect your technique is, trying to make that signature Geddy Lee sound leap out of a sub-standard rig with a sub-par instrument is going to be a challenge, to say the least. (Not that your rig or bass is sub-par - but I tried, like you, to get my Ibanez SDG 800 and my Peavey TNT 130 to sound like Harris and Lee and it just cain't be done!!)
That was the very reason I decided to stop trying to force a square peg into a round hole - I went out and got a MusicMan Stingray 5 and an Ampeg Rig. No other effects, no monkeying with setting tweaks - just consistent, reliable rock 'n' roll grit, grid, and growl! Flea sound - no prob! Tool sound - no prob! Rush sound - no Prob! Eq settings? Flat. Bass settings - moderately tweaked one direction or the other. Technique - years of practice, but really not much different from one to the next.
To get those tones live, playing with a band, I would think that a 2x10 would be a little under-whelming...
To get the grit and tone without real tubes, you have to "fake it" with overdrive or tube emulators... good luck.
But, to the OP's quest - good luck! I don't know what to offer as for settings - you got my best shot based on what the real gear actually sounds like. If the amp modeler does not sound that way or the instrument's wood/neck/electronics/eq does not want to go there, well... good luck!
Just because you dont see somthing sitting in front of your bass god doesn't mean its not there, millions of dollars will get you a guy who knows your stuff as well as you do, and he will take care of it for you. high dollar sound guys aint settin up for bar bands. and you would not need a high priced staff if all you did was plug into your amp and dazzle everyone with your great tone shaping fingers.