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Hooking up my PreSonus and Lexicon

I have this Studio One Channel tube preamp and a lexicon mpx 100 dual channel processor, and I was wondering how i should hook them up to my amplifier. I tried going from Amp-Presonus-Lexicon-Amp through my amplifiers send and return effect pannel, but when i slap a low E, my lexicon starts to clip my sounds and it distorts a little. Does anyone know how to fix this?