I'm not sure about that particular model QSC, but they usually require that you have a specifically wired speakon cable to operate a QSC power amp in bridged mono mode. Your typical speakon cable will come wired +1 positive, -1 negative. You'll need to open up the end of your speakon cable and re-wire it such that its +1 positive, +2 negative. This is a VERY simple operation that requires nothing more than a phillips head screwdriver.
DO NOT take my word for it. Consult your owner's manual first. My PLX1602 had a very clear description of the speakon wiring needed to make bridge mode operation possible.