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Before anything else, I'd get the bass set up by a pro. In particular, I'd make sure that the nut slots are cut to the proper depth
This was my experience. I played a Warwick Corvette for 20 years and my hand cramped in the same positions as the OP stated. The Corvette was not only heavy as hell, but it has thin neck profile, like a Jazz bass. A few years back I switched to Spectors which have a thicker neck profile and I no longer have cramping in those low notes.How thin is the neck, front to back? I had a MIJ Geddy Jazz for years. Great bass, fun to play. Very thin neck front to back. When I started playing out live, I realized after a few hours of playing my hand would start to feel crampy and hurt. Moving to thicker necks made a huge difference. No more issue.
Or get a 5 string and shift some of the parts to the B and E strings.OK, I'll volunteer to be that guy who proposes the most simplistic solution: get a short-scale 4-string.
I usually hike my neck up and hold my bass at a higher angle.
Perpendicular! Fingers to fretboard!