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Four 1x12 cabs is a good choice. Complete versatility to use as many as you need, easy pack and load, and they can be vertically stacked. Tweeters off on all but the top one.

So is there a difference (sonically/to the ear) of 2 2x12's vs a single 4x12?
I'm sure there is, because a 4x12 is likely to be built a bit small for the drivers. Companies want to save wood, have a cab that doesn't look too large, and save on shipping. There would be an economic motivation to scrimp on the size...if they make one at all.
A 2x12, on the other hand, is roughly like a tall 1x15. Much more likely to be a well-designed cab.
Also, there are many 2x12s to try; there are very few 4x12s.
I disagree with this entirely. My Peavey 412 has almost EXACTLY twice the internal volume of my Avatar 410. A 412 has only 1.5 times the surface area of a 410.
I wonder when the last time was that he had to move that himself (if ever)![]()
While I know that it isn't scientific (I'll let GB handle that), the 412 is hardly starved for air.
I think a mesa 4x12 is way more portable than a 2x12 or 4x10.
Do you have a concrete example to refute this with?
I'm sure there is, because a 4x12 is likely to be built a bit small for the drivers. Companies want to save wood, have a cab that doesn't look too large, and save on shipping. There would be an economic motivation to scrimp on the size...if they make one at all.
A 2x12, on the other hand, is roughly like a tall 1x15. Much more likely to be a well-designed cab.
Also, there are many 2x12s to try; there are very few 4x12s.
Just my opinion, but I have never heard a bassist sound good (live) through a 4x12. I know it worked for some legends like Entwistle but the bassists I've seen that have run the 4x12 cabs just don't quite have it, sound-wise.
But if it's the sound you want, go for it. I've always been a 4x10 guy myself, but that's just me.

The cab was *big* and a pain to schlep, but it sounded *great*. I broke windows with that cab...

How do you guys think 2 Avatar 2x12's sound together? I have one 2x12 and am thinking about adding another 2x12 or a 2x10. What do you guys think?