I played a mesa carbine combo a few months ago. It blew the walkabout away. It must be a discontinued model, but it had me "rethinking my tone". I don't have that amount of cash though.
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I know this is an old thread but one thing i know is mesa doesnt have a weight listed for the 400+ on their pdf for the amp. When a company doesnt lista a weight outright it means theyve got soemting to hide. So its heavy.
Could also be that the 400+ was developed back when 40-50 lbs wasn't considered heavy.