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Mixing Unbalanced Gear w/ Balanced Cabling???

Shouldn't be a problem. The R of a TRS connector just shorts to ground, or hangs in the air doing nothing. The unbalanced device doesn't notice that it's missing anything, and the balanced device doesn't care.
 
Over a short run it shouldn't be a problem. My only problem with it is that unbalanced cables can sound thin in high impedance circuits. That is an observation that I have made when experimenting with quad conductor mic cable as high-Z interconnect cable. It didn't hold up against a cable like Canare GS-6 that is designed for high-Z work.

I gotta ask this, but which digital audio interface has an unbalanced input? Most/all that I have used have balanced inputs that are compatible with unbal 1/4" TS plugs.

Also, outside of shorting out your phantom power supply if it were to be powered up, there isn't anything to lose by trying it and listening to the results.