Running a pair of 18" subs with only 2 10" for satellites is useless and insane.
All you will get is a mush of undefined lows. Leave this to DJs.
One sub is more than enough trouble for a live band.
I'm surprised that the KW181 doesn't have built in crossovers.
That's how 2-1 / 2-2 systems usually work the best, send everything to the sub and let it sort things out.
I ususally only run 1 sub. on the rare occasion that I use 2, I run 4 k 10 tops...
in the KW181 manual, it says to run full range signal to tops set to ext sub, then run out to sub.. this is opposite of what I thought which is full range to sub, then 100hz and above sent to tops...