What cabs are you considering using? Because in some circumstances that can be a savvy way to pair your cabs, and in other circumstances it can be kinda bad.
For example, if the 4 Ohm cab is two 12" speakers and the 8 Ohm cab is one 12" speaker, each driver will probably receive the same amount of power. That's could be a pretty good setup, assuming the speakers are all compatible and your amp can handle the load. (The Mesa Boogie Subway speakers are designed this way: You can pair the 1x12 (8 Ohms) with the 2x12 (4 Ohms), or the 2x10 (8 Ohms) with the 4x10 (4 Ohms), and so on.)
If you're pairing dissimilar cabs, you may end up with a system where you're effectively only hearing one speaker because the other speaker isn't getting enough power to match it in volume. Or other problems may arise.