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Pickups or Amp?

I'm playing a 5 string schecter through a mid 90's nemisis 410 amp. Most of the time the problem only occurs when I use my low b string. I get a horrible buzz sound instead of a nice deep bass sound, it also seems to get a bit fuzzy sounding when I hit the B note on the E string. Do you think it's more of a pickup problem or something to do with the amp itself?