So, I have always owned combo's. I recently purchased an amp and cab for more power. My 15 cab speaker was making a popping noise when turned up and really wasn't even that loud. I figured either the amp or cabinet was bad. Then I saw a thread about speaker Cable. I picked up a 12 gauge speaker Cable at my local dealer and BAM! Everything cleared up and the power seemed like it doubled!! I'm just thankful I didn't mess anything up before switching to the speaker Cable. So, YES the speaker Cable makes a difference!!
