One cool thing you can do with two combos, if you use any effects, is to split the signal -- with an A/B-Y box, or a tuner with two outputs, or whatever -- and then put your effects between one of those outputs and one of the combos, but not the other. This is especially useful if you're using any (of the many) effects that suck bottom end, as you still have one amp carrying the unaffected signal with full bottom end. I've done this with a B50R stacked on top of a B100r, sending the effects to the 50 and leaving the 100 clean and full of booty.
