The cathode stripping not the big deal at typical guitar amp voltages...not dealing with transmitters here.. is not really about the valves..
However, if you did not have a stand-by switch and your amp uses solid state rectification.... You would apply high voltage across every component in the amp including pre-amp stages...until the all tubes warmed up and draw enough current to pull down the voltages .... Typical Marshall that idles at 465V would see roughly 500V un-loaed across all components until tubes warm-up.. figure 6 to 8 seconds warm-up time.... The pre-amp filter caps and coupling caps may be rated at 400V during this 500V over-stress...sometimes not an issue, but if the amp is old..
If all your components are up to the task of high voltage over-stress for 8 seconds each time you turn your amp on..then I guess your all good..
There are cases such as with FOLLOWERS and CASCODE topology, where you can get a HEATER-to-CATHODE breakdown before the valves are warmed up....due to the higher voltage occurring at the cathode when the tube is cold.. Proper design can prevent this...but there are amps out there that have this issue.. Also need to be careful when the heater is floating on the DC voltage....
I like the STAND-BY switch....so I can switch out guitars quickly between songs without having to shut down the amp...I sort of treat it as a MUTE switch..