The most important issue is to select a driver that will work in the cab. Usually the original driver is your best choice. If you want to use a different driver, you need to research potential candidates, and then model how they will perform in the cab. A driver may be totally unsuitable for a given cab or you may be able to modify the ports a bit to get the tuning into an acceptable range.
Regarding 4 VS 8 ohms. People often make this choice because their amp makes more power at 4 ohms than 8 ohms. Some considerations:
1. How much power will the driver actually be able to handle? For bass you need to be concerned more with mechanical power handling than the driver's RMS power rating. The RMS power rating basically tells you how much wattage the voice coil can dissipate. But with bass cabs you need to be concerned more with cone excursion below 100hz. Cone excursion is determined by driver characteristics as well as how the cab is tuned.
2. How much louder will the 4 ohm variant play. When drivers come in either 4 and 8 ohms, the 4 ohm variant is often 1-2dB less efficient. So even if your amp makes double the power at 4 ohms, you only gain 1 to 2dB...and this is assuming the driver can actually handle all of the extra power.
3. When you push a driver close to its limits, it tends to experience power compression. This means actuals gains will be less than the calculated gains.
FYI Eminence publishes cab design docs for many of their professional drivers. I sorted this page by Eminence, 4 ohms, and 15":
Brand, Impedance, Nominal Diameter
There are two options. I suggest looking at the spec sheet and cab design doc for both drivers. To get these documents, select the driver and the scroll down about 1/3 page. There you will see a tabbed menu. Click Manuals and Resources and then scroll up a bit for links to the spec sheet and cab design doc.
One of the available 4 ohm drivers is an LF variant. These are usually not ideal for full-range bass. They are more like a subwoofer.
Good luck!