I am a fan of separates. Yes the prices are higher than most combo options, but I feel like the quality of the speakers and amps are generally higher in separates vs the value-based "all-in-one" combo options.
There are exceptions, like GKs higher end Legacy and Fusion combos. However you'll see that those are anywhere from like $900-1600, and not really much less than just buying the separates. The ins and outs, (direct out, effects loop, tuner out, etc) are generally much better/plentiful on a quality amp head vs a combo. This doesn't matter much for home practice, but can be a game-changer for gig situations and sending a good signal to FOH.
I also like to mix and match based on the sound I'm going for at a particular gig, or the volume and space requirements/limitations. I've got 4 heads and 5 cabs right now across a few brands and sizes.
Over Easter weekend I went and played at my in-laws' church a few hours away. Very simple, small church with seating for about 150. Since I was traveling I wanted to keep it light. Went with a little 110 and a Warwick Gnome amp. The amp and power, speaker, and instrument cables fit just perfect in the pocket of a Sterling bass bag I had on hand! Easy gig rig with just two items to carry - bass bag and cab.
If you tend to like to experiment and try new things, separates make that easier and more fun as well!
I share the above because I also really like having my 2x112 stack. If I didn't have that 110, I would have just as easily taken along one of the GK112 cabs in the pic. I just really love modular stuff. The options this approach gives me are just great.
Good luck!