If you're experiencing what many of us have, you need to lower the bass and raise both your mids. I have a 500 and 115 can and I drop the bass to about 10:00-10:30. I read that suggestion here in TB and it made a big difference in lessening the boom. Then I raise the lower and upper mids to 1:00-2:00, depending on the room. I usually leave the treble at noon.
I either run it without clean or with the vintage button in, but as you may have heard, it changes the tone structure quite a bit.
The gain is purely a boost so try running without it and use your volume control only. Then if you want to warm up the lows add gain to taste. I tend to run it 8:00-9:00.
Give that a try, maidenbass, and let us know if that helps any. I played through the 200 combo first and can attest it's got done booty! Harness that bottom end and you'll be surprised how nice it'll clean up.