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I have both a 410 and 212. I usually take the 410 if I don't "know" the venue. IMO it cuts through so I can hear myself better. I like the tone of the 212 better than the 410 but (for me) it's all about hearing myself.
I use an Epi UL410 or an older side-by-side Epi 212.
Good luck in your search.
Shindig
It depends on what you are doing. AT this point in time they have put more development $$$ into 10" speakers than 12" for Bass... If the 12" starts becoming more popular they will come out with new designs for us.
Like looking at 15" guitar speakers compared to 12"; hundreds of 12" designs with every tone imaginable...
I really like the form factor of a small, vertical oriented 212. Easy, lightweight, plenty loud for most gigs.
However, I've yet to hear a small 212 or a 2 x 112 stack that can keep up with a 410.
If you can only afford one, and have an vehicle that is large enough to carry it, a lightweight 410 can handle virtually any gig, and as posted above, is always a safe bet if you don't know the venue or band you are playing with.
I voted for the 212 because since I've been gigging with mine, FH sound guys have been commenting on how well the cab fills the rooms I play with bassy goodness. Additionally, since I schlep my own gear, I can carry the 212 (w/neos) more easily than I could a more traditional 410 rig. However, if your criteria is to hear yourself standing in front of the cab, the 410 will probably be better.
I would say it depends on who's making the cabs and what sound you want. All 4-10s don't sound alike, nor do all 2-12s. IMO it makes sense to audition specific cabs in both formats (and perhaps others) and not to tie yourself down to a decision beforehand.