guitarists do it all the time with 100 watt heads to tame the volume and/or overdrive the power section. but the trick is that you have to half the impedance setting on the amp to keep things properly matched - so if you were playing with the amp set to 4 ohms, you'd need to set it to 2. BUT, this is assuming you have 4 power tubes and are pulling 2 of them. if you have a sextet, not sure what you would do, probably not a good idea. with 12 tubes, i would imagine you need to pull six of them to get the impedance correct. at that point, you'd be better off just having a backup amp.
JR