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I tried them side by side at a Guitar Center and ended up by the 12. In fact the Scout has replaced my Mesa 400+.
There's a lot of info on these amps, have a look in here!
http://www.talkbass.com/forum/f15/mesa-boogie-walkabout-part-6-a-812562/

While some say it's tough to tame the lows, I never found it to be much of an issue.
How's the volume? A 1x12 doesn't seem as though it would be loud enough for me. (I currently play through a gk 2x10 combo)