1) Definitely get a sealed cab.
2) Do some research. There is some threshold for the T/S parameters where you can get an idea of whether the speaker will work well with a sealed cabinet or not.
3) You will be more in the realm of a "60's sound" or "SVT" type thing, not a hi-fi thing. Something like an Eminence 3012LF would probably _NOT_ be a good speaker for the job. You might do better with something that's more of a "guitar" speaker that's known for a solid low end in a sealed cabinet.
4) You'll want to be mindful of how much power you're putting through the cabinet. A tube amp like an Ampeg V4B might be a complimentary combination. V4B's are cool amps that you probably wouldn't regret buying too much in any event.
5) Treat this as an experiment. It might or might not work out.
I think the idea has some merit if you're going in a Cream-era Jack Bruce or Lemmy from Motorhead type tone. Be prepared for it to not work out and work so you aren't too exposed financially in that scenario.
KO