I'll take a shot at this. I am a pro bass player, and play 4,5 and 6 string basses, fretted and fretless, plus my current fav, a beautiful 5-string fretted acoustic bass guitar tuned EADGC. I had an ME-70 for a few years and just got an ME-80. When I am driving a band I am playing probably 99% clean (NO-FX). The 1%, usually chorus or other occasional special effects. But I do a lot of solo playing, meaning just me, no band. Solo bass, playing down in the meat and potatoes range, can get really boring to the average ear, so I like to play a lot of stuff higher up the neck. I use a looper (had a Gibson Echoplex and a Jam Man Stereo, now a Boss RC-300) and love to lay down beautiful arpeggios chord progressions, stack counterpoint harmonies and melodies on top of this, and solo over the top. So, to your question. For what I do, the Boss ME-80 is amazing. Out of the box you have to wipe out all of the presets stored in the 36 User areas, and build your own patches from scratch. Stay away from the Amp simulators entirely as well as most of the OD/DS effects (unless you crave some old school fuzz). I usually go for very clean, light accents, simple chorus, flange, phase, sometimes delay. Stay away from Reverb too. Useless on bass. I have played most of the multi-FX processors on the market and watched them evolve over the years. The ME-80 is the best, easiest, cleanest one (for what I do anyway) I have ever played with. Nice work Boss, you nailed it. BTW, I've never ever liked any of the Multi-FX processors made exclusively for bass and I've tried so hard to like them. I wanted to, but they just don't get it. That's just my $.02 anyhow. YMMV. -Evan