you guys answering no are wrong. the correct answer is yes you can, but dont.
+1
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you guys answering no are wrong. the correct answer is yes you can, but dont.

The question isn't are you supposed to...of course you're not supposed to because it affects your amp's and speaker's performance. But you certainly CAN. And guess what...I'm doing it right now, sitting here with bass in hand, SWR Workingman's amp hooked up to some crappy speakers to practice with. Been using this setup for years just to practice with. And guess what, the world hasn't ended, armageddon isn't happening (at least from what I can tell), and my amp and speakers have certainly not blown up.
What's a speaker cable do? It carries an amplified signal from your amp to your speakers. What is required to do this? A path for electrons to flow through. It doesn't matter what kind of wire or cable is used although it will certainly affect the performance of your amp and speakers if the proper cable isn't used.
I'm not recommending to do this but it's certainly possible. So for everyone that says you can't and not to take my advice because I'm like the uni-bomber living in a shack out in the woods, go back to college and study electrical engineering for a few years. I know it's helped me out more than a few times.
I could (at least theoretically) juggle ginsu knives but I don't think that it would be a very bright idea.
you guys answering no are wrong. the correct answer is yes you can, but dont.
I found a pretty good explanation of why it's a bad idea to use an instrument cable for speakers, even though you can plug it in and it will work, over here (PDF):
http://www.procosound.com/downloads/speaker_guide.pdf
And leave my mama out of it.![]()
Don't do it, but you can if you want, or don't want, but have to, if you will - GW Bush
There you go...the "almost" perfect answer is last paragraph, page 5...they also titled it "Why Can't I.....", not "Why Shouldn't I.."
Like I said before (basically) you MIGHT wreck your amp.
But, it's your choice.
And even in desparation, I would rip two ends off a gtr patch cord, steal the lamp from my hotel room, cut the cord off and solder the 1/4 " ends on...and be confident that my amp won't catch fire...I can't believe they even put that part in...
For that matter, in desparation you can use a 12V adapter to power you 9V effects....it will come on, stay on for about 8 seconds, and the Kablamo, time for a new ped....but technically it worked....for 8 seconds, just how desparate are you?
PS, yo mama, is a very kind and lovely person, so there!
Can I put diesel in my car that runs on unleaded? Sure. It will probably run.
Same effing thing...
Can you physically plug in an instrument cable? - Yes
Will the cab reproduce sound? - Yes
Is there a pretty good chance that you will seriously damage your amp? - Yes
Actually, lamp cord can be perfectly fine as speaker cord. It can take the heat.
Guess I'm an idiot then...LOL
As I said, spend some time studying electronics. I played for a few hours today, as noted before, with my 400 watt Workingman's head into a homemade cabinet using a 3 ft unbalanced (mono) cable...nothing but sweet sounds radiating from the speaker to my ears. I wonder how that happened!?!?!
No sound or instantaneous melt-down of the amp and/or speakers would mean failure. As stated, the question is "WILL IT WORK?". The answer is "YES, IT WILL WORK". The unabridged version of that answer is: "Yes it will work, however it is not recommended that you do so since the amount of current running through your cable may exceed it's rated value and thereby causing a short in the line aka frying one or more of the following and its components: speaker cabinet, amplifier, cable."
How is that?
What do you say, Howling Mob? 
Guess I'm an idiot then...LOL
As I said, spend some time studying electronics. I played for a few hours today, as noted before, with my 400 watt Workingman's head into a homemade cabinet using a 3 ft unbalanced (mono) guitar cable...nothing but sweet sounds radiating from the speaker to my ears. I wonder how that happened!?!?!
No sound or instantaneous melt-down of the amp and/or speakers would mean failure. As stated, the question is "WILL IT WORK?". The answer is "YES, IT WILL WORK". The unabridged version of that answer is: "Yes it will work, however it is not recommended that you do so since the amount of current running through your cable may exceed it's rated value and thereby causing a short in the line aka frying one or more of the following and its components: speaker cabinet, amplifier, cable. Proceed at your own caution."
How is that?
Can you put a tin foil ball in your microwave?