I have done it for when I've been in D-standard and have one song (Longview) that has to be Eb-standard due to open strings and it worked flawlessly. Of course, then we immediately added a song that needs the Drop-D for the same reason so I've switched back to E-standard and use Drop-D for everything that needs the low D and just use a Pitchfork for that one Eb song. It sounds a little synthy-ish but it kind of gets me closer to Dirnt's sound anyway since my tone isn't anywhere near his (by choice).