All of the above. I use a single preset to cover all of my needs. It does all of my input processing (noise gate, gain staging, high pass filter, compression) then it goes to all of my effects that I control with Anagram and a MIDI controller (all in stomp mode for a total of seven footswitches), then there’s an output block that sends 1/4” output 3 before the final section of the chain to be used with an amplifier, and finally after the output block the other outputs (typically only XLR output 1) goes through an amp sim, cab sim, low pass filter, and a limiter for my send to FOH and IEMs.Are you using the Anagram into an amp & cab on stage with a band ?
If so, just straight into the front of an amp with all of its EQ and level options, or into the FX return of the amp ?
Are you playing ampless/silent stages ? .... using IEM's to hear your bass and any relevant band input ?
With this setup I can use the same preset and cover anything I need. Studio sessions, IEM-only gigs, amp gigs, and it lets me rehearse at home using the same setup I’ll use on a gig. On top of all that, if the gig is a fly date the whole thing fits on a Nano board that easily goes in my carry-on backpack.