It is definitely worth performing an A/B. A DI means that you are going to be using the mic preamp, where if you go in with an unbalanced 1/4" plug you will probably be bypassing the pre. If you are coming in through a line input (or using the mic/line switch, you don't say what model interface you have) then you are basically using the internal "DI", designed for a hi-Z source.
I have done it both ways but since I often have a DI set up anyway I will use it. I'm using a Radial ProD2 most of the time. I was using the DO out on my Read Purity until I sold it, and before that I was using an Aguilar DB900. The Radial is their bottom of the line passive DI, but it still sounds fine. I have access to some better options if I feel the need, but I rarely do.