I'd suggest that Feynman wasn't entirely serious when he talked about scientific guesses. In the context of science, hypotheses are limited to notions which fall within the constraints of physical possibility. Thus, no credible scientist would posit that the extinction of the dinosaurs was caused by overconsumption of time-traveling jellybeans, or that the Moon is made of green cheese.
As for the present case, the analogy suggesting that improvements in transportation since medieval times are somehow comparable to interstellar travel is off by many orders of magnitude. It is true that humans have drastically increased the speed at which we can travel between two points on Earth. However, the distance between any two points on this planet simply does not compare to the sheer expanse of the Universe. Our present estimate is that the Universe extends about 46 billion light years in every direction. Even at the speed of light, there is simply no way to traverse that distance in a lifetime, let alone a thousand lifetimes. Thus, unless our present understanding of the laws of physics is fundamentally wrong, interstellar travel, beyond perhaps the nearest stars, will forever remain nothing more than a fantasy.