I live in a townhouse, and I like my neighbors (and I practice at odd hours sometimes), so I practice in headphones. Most of my gigs are ampless, so what I hear at home and what I hear on stage are very closely related - practicing through an amp would be less like a gig than practicing in headphones.
Most of the time, I practice without my pedalboard - what my pedalboard does is subtle; it has some eq that makes it easier to hear pitches and timing than without it. So, practicing without my pedalboard teaches me to listen more intently for cues. Most folks, at the gig, have a harder time hearing what they're doing than when they practice. In my case, it's a bit of the opposite, which puts me in a very happy place.
Most of the time, I practice without my pedalboard - what my pedalboard does is subtle; it has some eq that makes it easier to hear pitches and timing than without it. So, practicing without my pedalboard teaches me to listen more intently for cues. Most folks, at the gig, have a harder time hearing what they're doing than when they practice. In my case, it's a bit of the opposite, which puts me in a very happy place.