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drop-tuning

entirely too many variables
how stiff is your neck?
which strings do you have on? (flats or rounds)
how comfortable are you with playing on lower tension?
how low are you dropping?

I've got some Cobalt Flats on right now that I usually keep tuned to E standard, but sometimes I go as low as D Drop C.
If I leave it in D Drop C overnight, then I'll have fret buzz in the morning.

If you're going for C# standard or lower, then I'd recommend using heavier gauge than when you tune to E standard.

ghs-bass-boomers-h3045-50-115-heavy-97064.jpg
 
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Try DR DDTs.
You can use the same gauge as you do now, and drop tunings feel like standard tunings. I love them for C# and lower. No setup required.
That may be the marketing hype from DR but that's not entirely true.
If you use the same gauge then drop a string by 2 semitones the absolute tension will inevitably fall to 79% of it's former value. To compensate and reduce floppiness, the strings have thick cores to create deliberate stiffness (not good for tone and harmonicity) to raise 'perceived tension'. So they will feel different due to a different type of 'tension', some absolute (scientific) tension is shifted to 'stiffness perceived tension'.

A setup is necessary with almost any string change, if the gauges are the same the extra stiffness means a change of saddle intonation. Because you will be dropping, saddle heights and the truss rod will also probably need adjusting.
 
That may be the marketing hype from DR but that's not entirely true.
If you use the same gauge then drop a string by 2 semitones the absolute tension will inevitably fall to 79% of it's former value. To compensate and reduce floppiness, the strings have thick cores to create deliberate stiffness (not good for tone and harmonicity) to raise 'perceived tension'. So they will feel different due to a different type of 'tension', some absolute (scientific) tension is shifted to 'stiffness perceived tension'.

A setup is necessary with almost any string change, if the gauges are the same the extra stiffness means a change of saddle intonation. Because you will be dropping, saddle heights and the truss rod will also probably need adjusting.
Well, I was speaking from my own experience.
Not quoting "marketing hype".
And I fully understand what you're saying.
However, my basses with DDTs feel great, and required no setup adjustments.
Including intonation.
And yes, I do know how to properly make said adjustments.
 
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I've been experimenting with BEAD tuning. Tried the chrome flats which did okay, but not great.
I'm now using ghs nylons which seem to be doing much better. I did have to raise the the strings up. Has anyone else tried nylons for drop tuning? Also, dh doesn't make these anymore, so I'll have to buy another set if I want to have it setup with that tuning. I bought a 5 string, but I'm finding that it's heavy and wide, and I don't really use the higher strings on my 4 string even with the BEAD tuning, so I'd rather use it if I can find good strings to hold the tone. If I go with thicker strings, I'll have to have the nut changed to accommodate them.