The difference in 4 and 8 ohms is the power rating they pull. For example the E300 head runs at 320 watts at either 4 or 8, but most amps will run 225 watts at 8 ohms and 300 at 4 ohms, ... or similar. It will make no difference on the 300.
I have run both the 800/410 rig and a 550/215 rig. The 410 is not lacking on lows by any means, you can play with then and see the sound you can derive and find what you do and dont like.
For the studio, I always ran the DI from my Edens straight into the board, never mic'ed a cab.