The response is a product of the electronics (easy to simulate in LYSoice) and the time delays inherent in a wave travelling aling the string - you use transmission lines to model that. For a 2 pickup system, you get an FIR filter with 2 positive coefficients (the wave traveling towards the bridge), and two negative ones (the wave returning from the bridge). Every string has a different response, as a higher tuned string has a greater propagation velocity.
If you understand the Physics and electronics involved, it’s relatively straightforward. If not, it’s voodoo.