I have no experience with the BX500, although am also very interested in checking them out. I especially like the 2-ohm capability, the graphic EQ, and the defeatable tube pre. It's just although Carvin has great customer service, Genz Benz has to be hands down the best in the business. I'm currently experiencing problems with a second-hand NeoPak, and agedhorse has been replying to my emails faster than I can write them. You never get service like that where I'm from.
I've also written Genz before regarding the Shuttle 3.0, and got a 'gone fishin' reply from Jeff. He replied the next day, while he was on vacation, and I didn't even buy the amp yet. He was very accomodating, answering even the dumbest questions I had. He even got Fender Germany to find a bag for my Neopak for me.
Anyway, back to the topic. I've heard a few soundclips of the BX500, and in some settings, I think it sounds similar to the NeoPak, with a bit more low mid bump. I think the 'typical' Genz Benz sound is anything but muddy, but then I also didn't find any of the Markbasses I've tried to be muddy; they sound more high-middy for me. I just plain like how my Neopak is voiced, just wish it had more power.