I definitely don't like running the Volume so high that it causes distortion before the Boost circuit. That is not how this amp should be run IMHO.
I currently have my Boost at 11:30, my Tweeter at 12:00 and my Woofer at 14:00. If I run the Masters much higher than this, the amp gets a little hissy, but not what I would call problematic for live work. It probably would not fly in a recording studio though. I don't think I would ever run the woofer Master past 15:00. The Woofer amp is noisier when the Woofer X-Over switch is engaged. Not a surprise...extra circuitry adds noise.
The Boost control is just an attenuator on this amp as well. So you can keep the level hitting the Boost circuit the same by increasing the Volume while decreasing the Boost control, or by increasing the Boost control while decreasing the Volume. But the best S/N ratio is with the Volume set fairly high.
I'd see tweeter hissing, but not the woofer to be honest. Unless you crank the treble I guess. I never use the tweeter, that control is always off (turned down all the way to be specific) for me. Tweeter doesn't work well with OD, fuzz and distortion pedals and I tend to use those sometimes. GK RB love "riding the rails" with a mix of boost growl and cranked up master (woofer). Kind of like a tube power section. It opens up headroom as well.