I've been playing since the mid 1960's.. and with few exceptions, I've never sold off my old gear (I want to find my acoustic 360 and 1971 Ric 4001.. beyond that I still have it all) ... As I hit my 60's, my back has forced me to get something light and powerful. As a cost savings, I'd stick with the used market.
My current rig varies... the bottoms are aguiar GS112 (1-12") and a pair of GS-210 (I usually use only 1 of them, I saw the second on sale so I had to grab it!) .. this is now defunct and is the 2-10 version of the GS410... That easily covers 200-500 seat room, depending on what you put on top. I wish I could recommend a single head, but I screw around with many...I purchased two broken Hartke HA-7000's (both were easy low cost fixes) for about 100-200 bucks each on ebay... this has a variable crossover so I play with it depending on the room and the musical idiom. For some gigs that cross between slap/modern sounds and traditional 70's rock, I bring both in heads (as they stay in the van anyway) as I hate playing with the settings.
I am electrical engineer, I spend lots of time repairing Crown and Mackie (since you have to purchase some of the specific descretes in quantity) and I'm not a big fan of off the shelf power amps for bass, unless you have a place to limit long term vibrations or you have old solid Phase Linear or Crown-type amps were the internals are rock solid. Newer amps have limited repairability even though they weigh very little with higher power.. this is, in part, due to the replacement of toroidal coils.. Remember, whatever you choose in the trade-off of cost, tone, weight, long term reliability, power (pick two of those and the other elements can diminish).
Best Wishes!