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How do buffered pedals and dedicated buffers work?

I sold my multi effects pedal a few months ago because I hated feeling limited by the effects that it provided and not being able to choose my own individually based on taste. And so, I sold the unit and began my journey of trying and buying different individual pedals. I play indie rock (Dreampop to be more specific) and my current board consists of the following pedals.

From amp to guitar:

Tc Electronic Ditto Looper
Tc Electronic Hall of Fame 2 Reverb
EHX Memory Toy
EHX Nano Clone
EHX Stereo Pulsar Tremolo
Tc Electronic MojoMojo Overdrive

The board is currently holding six pedals with about three or four more planned for the future (Flashback delay 2, Spatial Delivery by EQV, Dunlop Mini Wah and PolyTune 3).

I thought that having a chain of six pedals wasn't degrading my guitar tone... Until I plugged the guitar straight into the amp. Man, I'm losing quite a bit of tone and it's made me decide that it's time for a buffer. Hall of Fame Reverb 2 has a buffered bypass mode which I activated and it isn't doing anything to my signal. The manual on the Tc Electronic website recommends having a buffered bypass pedal at the beginning and end of the chain. I know that Polytune 3 has the Bonafide Buffer integrated into it, but a friend of mine who has the pedal told me that it's just another buffered bypass switch like the one on the Hall of Fame 2 which he also has.

This leads me to ask, is worth it to get a dedicated buffered or should I just buy the Polytune 3?
My pedalboard is gonna keep growing and I don't want to lose my guitar tone in a sea of true bypass pedals.
 
Have you ruled out your cables?
Now that you mention it, I have not. The cable that goes off of the Ditto Looper and into the amp is a 20ft Fender cable. From the looper to the MojoMojo which is the first pedal on the chain are 3 PlanetWaves patch cables, an EVH patch cable, one small path cable that came with a pedal I had a few years ago and it all finishes with a 10ft Fender cable that goes into my guitar