It is not watts or electrical power that matters. What matters is the sound-pressure level achieved.
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In order to radiate the necessary acoustic power fairly evenly into a large room, you will usually need multiple cabs facing in different directions. That's because a single cabinet, that might be fine for a small venue, would usually be far too directional to be sufficient.
Because the sound has to travel farther in a large room, and because the acoustic power will fall of proportional to the square of the distance traveled, a greater sound-pressure level will be required at the source in order for you to be heard properly in the back of a large room (unless, you've placed speakers back there).
Another factor in achieving the necessary acoustic power is the reflective properties of the room.
Large rooms are also typically occupied by more people who will raise the "noise floor," requiring greater sound pressure level in order to be heard above the din. That is, unless those people are sitting quietly in their seats listening to you.
All of this (and more) combines to make it entirely inappropriate to give an answer regarding how many watts are required in any venue. Suppose you say that you'd like to achieve 85 dB SPL fairly uniformly in a room. One would have to consider all of the factors (and more) mentioned above in designing a system that would do that.
Let me take a stab at a rough practical answer. I'd say that if you built a system that could achieve, say 125 dB SPL, one meter from each of two cabinets, you'd have a system that could cope with a very large variety of rooms. How many watts that will require will depend upon the cabinets themselves and could easily vary
by a factor of ten or more depending on which cabinets you choose.