some people love their mixed cab rigs, and that's cool. but the science of audio doesn't magically stop applying to a mixed cab rig just because you like it. i love my old 810 but audio science will tell you that it beams mids and highs, and sure enough it does. and a mixed cab rig is going to have possible phasing issues as well. doesn't mean it won't sound great, but it does mean that the possibility of phasing issues is greater, and the results are unpredictable, whereas using identical cabs guarantees uniform results.
however, the 410/115 combo just makes no sense on any level except looks, imho. most 410's go as low as any 115, and have about twice the output with the same amount of wattage. the reason it became popular is because of ads where they'd put a 410 and 115 together to show off more of their product line in the same ad space, and people would see it and say, "hey! little speakers for highs, big speakers for lows...brilliant!" thats what you call "engineering by looks."