Sometimes it's not doing the dumb thing yourself, but allowing someone else to do it for you.
While using my Carvin AG100D three channel combo amp, I offered one of the unused channels to the drummer who for the first time was using a newly purchased electronic drum kit. While I was busy tending to other things, he was unsure how to hook things up while getting other unsure people to get things figured out and working. All this was taking place at the drum kit, and involved them trying several adapters, a couple of DI's and a powered monitor amp (for stereo). I had the amp powered up and his instrument cable plugged in to my amp from the start before any of this began and assumed they would figure it out, so I left to use the restroom before we started. When I came back they seemed to have it working and just needed a volume adjustment, done.
I noticed after a few songs, the sound was beginning to fade and distort with both my bass and his drums, but made it through the gig sounding pretty bad. It took me using it a couple more times (worked fine for up to 20 minutes before fading out) before realizing it had been permanently damaged from something being hooked up wrong by the drummer and associates using trial and
error. No hard feelings, just a hard lesson. I know, " fire the drummer" haha
Thankfully though, Carvin made their combos with an external speaker connection, allowing me to still use the 112 cabinet portion along with the extension cab for a 212 setup. Looks a little odd using a head on top of a built in head, but it works great.