I would say if you bass is brite to begin with go with the low rider to get more of a deeper tone for your B and E strings. I would say for DR's the high and fat beams and low riders all have good highs and decent mids, the biggest difference is going to be the lows. I play a Spector and it's a bright bass so I use Low Riders, I play a Rick and use highbeams on that since it's a low and growly bass to begin with. Not to say High and fat beams don't have a good low tone they do. Think of it this way Highbeams are the brightest strings, Fats are the midrange, Low riders are a bit deeper in tone. All are very close to each other in my opinion, but the slightest difference in tone and tension in combination with your bass and compounds it's made from will have a big difference in your overall tone. You also have the Sunbeams by DR, they are nickel with a steal round core, so in thoery the nickel is softer sounding but the round steel core still gives it brightness, the low riders are steel with a hexcore, the steel gives it brightness but the hex core gives it depth and a deeper tone. In a nut shell DR's are very flexable and it all depends on what sounds good in combination with your equipment. I like them all depending on what bass I am playing, you may have to spend a couple of bucks and try a few types out.