That's a tough question to answer. I could be many things. Without knowing your whole setup, number and type of drum mics and their placement, FOH speakers, mic types and number of singers, monitor set up, backline amp and placement, etc., etc.
General advice: If you are getting low end rumble or feedback on certain notes only, you could be dealing with room mode problems. (Do a seach and learn about this. Too much to go into to explain it properly.) Moving you cab slightly can get rid of that problem. (It could also cause an issue in a different area.)
A mic could be the problem as well. I would check the placement of the drum mics first. Also, if you are boosting frequecies on a drum mic too much, it can cause problems. If you lower the eq or change the frequency if you have a sweepable mid, can you get it to go away?
High passing the vocal mics can clean things up too. Most newer boards have a 75 or 80 high pass button on each channel. This can really cut down on boomyness on stage.
That last thing I would suggest is lowereing the bass on your amp. If you have a full pa (subs and tops) you can often cut the lows on our rig by a huge amount. This will help clean up the sound on stage as well as let the pa do the heavy lifting on the low end.
If you could give a better discription of your overal set up, we could help you pinpoint the issue.
Good luck!