After twiddling around with the Mesa for about 3 hours in the store I managed to find a really nice sound I liked with a Yamaha John Myung signature bass. I'm running an Ibanez BTB 406 with it, EMG 45DC's stocked at the neck & bridge. I'd be more inclined to get the 4X10HLF if it's the case that i'm going to be losing some high end. The band I am in plays kind of progressive Metal with a melodic touch, and I find myself on those wee little high frets a lot of the times doing triple harmonies or leads over top of the guitars. I ran the 8X10 with a SVT 5-Pro also at a previous gig, and managed to also receive a very nice defined tone, good on the highs but they lacked the clarity that I seemed to find with the Mesa, and I've always been a fan of the Mesa guitar products (mainly the dual rec w/ 6L6's driving it). In the end, I think I'll stick with the 4X10 to receive the best clarity on the highs along with the low end that I want people to more feel and be shaped by the guitar tones rather than a "IN YOUR FACE" low sound that a lot of bassists try to achieve in the Metal genre. It muds up any sound (esp. live) that you are trying to achieve.