I haven't played a VB2.
The BB750 is a very cool amp IMHO. But I wouldn't pay a premium for it.
I have the BB750's big brother, the Titan V12. The BB and Titan share the same preamp design. The voicing is pretty different from the Carbine. I have an M9 which is clean with huge lows and aggressive high mids. To my ears the Titan is warmer/more mid focused and it lacks the extreme LF extension of the Carbine. The Titan has full lows, but it's not super deep like the Carbine. The Titan was intended to be very tubey and it has a switchable drive circuit that is based on the Mesa Bottle Rocket.. The drive circuit has it's own baked in voicing that further accentuates the low mids.
AFAIK the BB750 is even more tubey than the Titan because it has a smaller output section. The BB750 is rated 280W at 8 ohms, 550W at 4 ohms, 750W at 2 ohms. Some users felt the BB750 was weak and needed to be run at lower impedance to make good power. I believe it's no longer recommended to run them at 2 ohms due to reliability issues. Also, if the BB750 has problems, getting it repaired may not be possible due to lack of suitable replacement parts. I believe it's a fairly challenging amp to work on, so if a repair is to be attempted it really should be sent back to Mesa for factory level service.