I would not use a room mic, with pairs of mics on one cab I have found they either need to be properly capsule aligned (ie, the bit which actually reacts to the incoming sound on each mic is the same distance away for the cab) so they are completely 'in phase', or the room mic needs to be far enough back to not phase badly with the close mic.
Bass is a bit non-directional, so a room mic may phase a bit worse with a close mic compared to the same setup with a guitar amp. If it ends up sounding cool then awesome, but be prepared for one or the other mic not being useable in the mixdown!
I would have both mics capsule aligned, as close together as possible and about 6" off the cab as a start. I like the sound of mics just off the center of the cone, a bass needs that larger than life extension you get in the center of the cone. the thinning effect as you get to the edge is not something I am into, but you may like the clear definition you get on the outer regions of the speaker.
If you can't decide maybe have the mics capsule aligned but one of them on the edge of the speaker, one in the middle. The characteristics of the mics will determine what works best. Once you have both signals going in they should, if phase aligned, work together well. If you have one mic in full and then bring up the other it should change the character of the sound without messing up the frequency balance. Then you can work out what you like best. If you want the sound to loose definition and sit back more then move the mics backwards from the speaker, together, if you want an even more clinical sound then a few inches forward may work.
experiment, and as long as you are always aware of phase and what the two mics are doing together, you will be ok. Theres nothing more annoying than having two mics that sound great individually which sound rubbish together, even when manually phase aligned!