Historically, I've enjoyed scooped low mids and boosted high mids (~300 & 1.2K respectively). However, I'm starting to realize that boosted high mids require a lot of accommodation from the mix since the vox and guitar are often very present around 1-2k. It seems to me that boosting high mids is paradoxically felt more than heard just because of the density of information in that spectrum. I like boosted low mids when they are in front of the low end tonally, that gives that active bass type growl.
I do find that if I boost BOTH the low and high mids, I can get a really aggressive sound that cuts like butter even at lower volumes, but there's a time and place.
Oftentimes, when your system is truly flat in the mids (like my VTDI), it only takes a small boost "<3dB" to give you the needed presence.