I was actually hoping to open a can of worms with this post as it obviously turns to dark matter on this particular note. Tell us is this a ported cab or sealed? I'm not familiar with the new stuff.
If it is ported you could possibly remove the port tubes if they are the removable kind and lengthen the tube slightly and move the problem to LIKE D or some note nobody ever uses.
I find it interesting it isn't just at one note but all over the spectrum. SO each octave is a problem, this is major wierd.
Do your buddies or spouse or somebody else hear the same flat response? I know this sounds hokey but lets eliminate your brain vibrating funny first.
I got to a volume level here that my vision actually blurred a couple weeks ago. Wasn't something I expected to have happen was a bit scary and exciting all at the same time.
I was looking at a video monitor back in 1988 and somebody said something to me I didnt agree with and I did a POO POO blowing air through my lips where the my lips vibrated, you know what I mean. The video monitor started losing sync. Turns out the frequency was the same as the monitor's refresh rate and me and my business partner could make the vision freaked out when we did this.
Maybe I broke something, no... But this could be 100% in the amp/cab, the pickups might be flakey or you might have a physical condition. Lets eliminate you first. BOB
BOB