I suppose it depends on your subs. Personally, I find having bass, drums, guitars and vocals all coming out of your mains sounds a little muddy.
Then again, I am not really a sound guy so I am guessing you probably are right.
If you don't sonically assign the vocals and instrumentation correctly, that's whats gonna happen. I see where you're coming from, though. The low end is supposedly the resident domain of bass and kickdrum so why not take advantage? Problem is that there's a lot of harmonic content that falls outside the capability of any sub enclosure.
Riis