I would start out with that amp and cabs not bridged. Run each one off of its own channel. See if this meets your volume needs. Its a very powerful head in bridge mode, more than capable of toasting two of those cabs. See if it meets your needs in dual mono first.
Ok starting from left to right.
Drive - Bring it up until you reach your desired amount of grit
Leave your contour flat, always and forever.
Compressor - If you can hear it greatly effecting your tone, turn it down. Should never hear it working
Bass - leave it at noon, if not cut a tad
Low mid - Set it at 100 Hz kick it up a small bit
High mid - Will depend on your play style and bass set up, cutting works better here
Highs - leave at noon if not cut.
GEQ - I would start with this off. If you just cant get what you want with out it start with it flat and experiment with cutting frequencies. Very small boosts, and the right cuts will be more effective than large boosts.
Cross over - Dont use it, run both dual mono, or bridged if you need a bit more, but be careful.